hrp0094p2-457 | Thyroid | ESPE2021

A case of complete atrioventricular block after initiation of methimazole in a patient with Graves' disease associated with Down's syndrome previously undergoing cardiac surgery

Sawano Kentaro , Hiroshima Shota , Shibata Nao , Nyuzuki Hiromi , Ogawa Yohei , Nagasaki Keisuke

Background&: Arrhythmias associated with hyperthyroidism are mainly tachyarrhythmias, such as sinus tachycardia and atrial fibrillation. In comparison, hypothyroidism shows several electrocardiographic changes, including sinus bradycardia, low amplitude QRS complexes, QT interval prolongation. There are few reports of bradyarrhythmia with hyperthyroidism, and it remains unclear.Case: The patient is a 13-year-old girl with Down's syndrome. She underw...

hrp0094p2-460 | Thyroid | ESPE2021

Re-evaluation of the prevalence of permanent congenital hypothyroidism in Niigata, Japan: A retrospective study

Nagasaki Keisuke , Nyuzuki Hiromi , Shibata Nao , Sawano Kentaro , Hiroshima Shota , Ogawa Yohei

Introduction: Although newborn screening (NBS) for congenital hypothyroidism (CH) in Japan started more than 40 years ago, the prevalence of CH remains unclear. Prevalence estimations among the NBS-positive CH individuals include those with transient hypothyroidism and transient hyperthyrotropinemia, and re-evaluation with increasing age is necessary to clarify the actual incidence. Thus, we re-evaluated the incidence of permanent CH.Subjects and Methods...

hrp0092p3-54 | Diabetes and Insulin | ESPE2019

Relationship Between Chloride Infusion and Base Excess in Initial Treatment of Pediatric Diabetic Ketoacidosis

Sawano Kentaro , Nagamatsu Fusa , Shimura Kazuhiro , Abe Yuki , Izumita Yukie , Ogawa Yohei , Komatsu Nagisa , Takishima Shigeru , Nakamura Akie , Nyuzuki Hiromi , Yamaguchi Takeshi , Muroya Koji , Watanabe-Yamamoto Sayaka , Nagasaki Keisuke , Saitoh Akihiko , Hasegawa Yukihiro

Background: In initial treatment of DKA, volume expansion should begin with 0.9% saline to restore the peripheral circulation. The use of large amounts of chloride-rich/bicarbonate-free fluids may cause the rapid development of hyperchloremic metabolic acidosis, which is described in ISPAD Clinical Practice Consensus Guidelines 2018.The severity of DKA, defined by pH, HCO3- Base Excess (BE), is one of the factor...